FORMATION OF HYDROXYL RADICALS ON REACTION OF HYPOCHLOROUS ACID WITH FERROCYANIDE, A MODEL IRON(II) COMPLEX

被引：114

作者：

CANDEIAS, LP

STRATFORD, MRL

WARDMAN, P

机构：

[1] Cancer Research Campaign Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR

来源：

FREE RADICAL RESEARCH | 1994年 / 20卷 / 04期

关键词：

HYPOCHLOROUS ACID; HYDROGEN PEROXIDE; HYDROXYL RADICALS; IRON; FENTON REACTION;

D O I：

10.3109/10715769409147520

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypochlorous acid reacts with the model iron(II) complex, ferrocyanide (Fe(CN)64-) in aqueous solution with the rate constant 220 +/- 15 dm3 mol-1 s-1. Free hydroxyl radicals are formed in this reaction in 27% yield as shown by the hydroxylation of benzoate to give a product distribution identical to that of free (radiolytically generated) hydroxyl radicals. This reaction is three orders of magnitude faster than the analogous reaction involving hydrogen peroxide (the Fenton reaction), suggesting that the hypochlorous acid generated by activated neutrophils may be a source of hydroxyl radicals.

引用

页码：241 / 249

页数：9

共 23 条

[1] BIOLOGICAL REACTIVITY OF HYPOCHLOROUS ACID - IMPLICATIONS FOR MICROBICIDAL MECHANISMS OF LEUKOCYTE MYELOPEROXIDASE [J].