DIABETIC NEUROPATHY AND THE MICROCIRCULATION

被引：85

作者：

FLYNN, MD

TOOKE, JE

机构：

[1] Department of Diabetes and Endocrinology, Prince Philip Hospital, Llanelli, Dyfed

[2] Department of Vascular Medicine Diabetes Research, Postgraduate Medical School, Exeter

来源：

DIABETIC MEDICINE | 1995年 / 12卷 / 04期

关键词：

DIABETIC ANGIOPATHIES; MICROCIRCULATION; DIABETES MELLITUS; DIABETIC NEUROPATHIES;

D O I：

10.1111/j.1464-5491.1995.tb00480.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is a close relationship between the abnormal microcirculation in diabetic subjects and diabetic neuropathy. Neurogenic factors play a prominent role in the regulation of the microcirculation. In diabetic neuropathy, damage to these mechanisms results in a profound haemodynamic disturbance with increased arteriovenous shunting, abnormal postural regulation of blood flow, and abnormal inflammatory responses to tissue injury. Abnormal neurogenic regulation of microvascular haemodynamics may contribute to the development of microangiopathy manifest as increased basement thickening and both are undoubtedly implicated in the pathogenesis of diabetic foot ulceration. In turn it is now recognized that microvascular abnormalities may contribute to the ischaemic aetiology of diabetic neuropathy.

引用

页码：298 / 301

页数：4

共 29 条

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