ONE-POT REACTION FOR THE SYNTHESIS OF M(7)G(5')PPPG AND M(7)G(5')PPPA BY USING AN ACTIVATABLE BIFUNCTIONAL PHOSPHORYLATING REAGENT

被引:17
作者
FUKUOKA, K
SUDA, F
SUZUKI, R
TAKAKU, H
ISHIKAWA, M
HATA, T
机构
[1] TOKYO INST TECHNOL,DEPT LIFE CHEM,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN
[2] CHIBA INST TECHNOL,DEPT IND CHEM,BIOORGAN CHEM LAB,NARASHINO,CHIBA 275,JAPAN
关键词
D O I
10.1016/S0040-4039(00)79966-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new bifunctional phosphorylating reagent 1 was prepared and employed for the syhthesis of the cap structure, m(7)G(5')ppG and m(7)G(5')pppA in large scale without using any protecting groups starting from the corresponding nucleoside-5'-phosphates.
引用
收藏
页码:1063 / 1066
页数:4
相关论文
共 18 条
[1]   STUDIES ON PYROPHOSPHATES .3. NEW METHOD FOR SYNTHESIS OF NUCLEOTIDE COENZYMES BY MEANS OF DI-N-BUTYLPHOSPHINOTHIOYL BROMIDE [J].
FURUSAWA, K ;
SEKINE, M ;
HATA, T .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (16) :1711-1716
[2]   HUMAN BETA-GLOBIN PRE-MRNA SYNTHESIZED INVITRO IS ACCURATELY SPLICED IN XENOPUS OOCYTE NUCLEI [J].
GREEN, MR ;
MANIATIS, T ;
MELTON, DA .
CELL, 1983, 32 (03) :681-694
[3]   SYNTHESIS OF NUCLEOSIDE DI-PHOSPHATES AND TRI-PHOSPHATES VIA NUCLEOSIDE 5'-PHOSPHORIC DI-N-BUTYLPHOSPHINOTHIOIC ANHYDRIDE INTERMEDIATES [J].
HATA, T ;
FURUSAWA, K ;
SEKINE, M .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1975, (06) :196-197
[4]   SYNTHESIS OF ALPHA,GAMMA-DINUCLEOSIDE TRIPHOSPHATES - CONFRONTED NUCLEOTIDE STRUCTURE FOUND AT 5'-TERMINUS OF EUKARYOTE MESSENGER RIBONUCLEIC-ACID [J].
HATA, T ;
NAKAGAWA, I ;
SHIMOTOHNO, K ;
MIURA, K .
CHEMISTRY LETTERS, 1976, (09) :987-990
[5]   SYNTHESIS OF S-PHENYL NUCLEOSIDE PHOSPHOROTHIOATES [J].
HATA, T ;
SEKINE, M .
CHEMISTRY LETTERS, 1974, (08) :837-838
[6]   MOLECULAR DESIGN OF A EUKARYOTIC MESSENGER-RNA AND ITS CHEMICAL SYNTHESIS [J].
IWASE, R ;
MAEDA, M ;
FUJIWARA, T ;
SEKINE, M ;
HATA, T ;
MIURA, KI .
NUCLEIC ACIDS RESEARCH, 1992, 20 (07) :1643-1648
[7]   A NEW METHOD FOR THE SYNTHESIS OF CAPPED OLIGORIBONUCLEOTIDES BY USE OF AN APPROPRIATELY PROTECTED 7-METHYLGUANOSINE DIPHOSPHATE DERIVATIVE AS A DONOR FOR THE TRIPHOSPHATE BOND FORMATION [J].
IWASE, R ;
SEKINE, M ;
HATA, T ;
MIURA, K .
TETRAHEDRON LETTERS, 1988, 29 (24) :2969-2972
[8]   AN EFFECTIVE METHOD FOR THE SYNTHESIS OF THE CAP STRUCTURE OF EUKARYOTIC MESSENGER RIBONUCLEIC-ACIDS [J].
KAMIMURA, T ;
OSAKI, Y ;
SEKINE, M ;
HATA, T .
TETRAHEDRON LETTERS, 1984, 25 (25) :2683-2686
[9]  
KONARSKA MM, 1984, CELL, V38, P731, DOI 10.1016/0092-8674(84)90268-X
[10]  
NAKAGAWA I, 1980, SYNTHESIS-STUTTGART, P556