DO C-H...O HYDROGEN-BONDS CONTRIBUTE TO THE STABILITY OF NUCLEIC-ACID BASE-PAIRS

被引：104

作者：

LEONARD, GA

MCAULEYHECHT, K

BROWN, T

HUNTER, WN

机构：

[1] UNIV MANCHESTER,DEPT CHEM,MANCHESTER M13 9PL,LANCS,ENGLAND

[2] UNIV EDINBURGH,DEPT CHEM,EDINBURGH EH9 3JJ,MIDLOTHIAN,SCOTLAND

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | 1995年 / 51卷

基金：

英国惠康基金;

关键词：

D O I：

10.1107/S0907444994004713

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The possible formation of inter-base C-H...O hydrogen bonds in AT, A.U and certain non-Watson-Crick base pairs is examined. A geometrical analysis in conjunction with implications for the thermodynamic stability of the base pairs suggests that C-H...O hydrogen bonds could form in nucleic acid base pairs. They may alleviate destabilizing interactions that would arise if an unsatisfied hydrogen-bond acceptor were present and mediate secondary hydrogen-bonding effects in these base pairs.

引用

页码：136 / 139

页数：4

共 22 条

[1]

BROWN T, 1993, CHEM BRIT, V29, P484

[2] CODON-ANTICODON PAIRING - WOBBLE HYPOTHESIS [J].