BENZIMIDAZOLE CONDENSED RING-SYSTEM .9. POTENTIAL ANTINEOPLASTICS - NEW SYNTHESIS OF SOME PYRIDO[1,2-A]BENZIMIDAZOLES AND RELATED DERIVATIVES

被引：133

作者：

BADAWEY, E

KAPPE, T

机构：

[1] UNIV ALEXANDRIA, FAC PHARM, DEPT PHARMACEUT CHEM, ALEXANDRIA, EGYPT

[2] KARL FRANZENS UNIV GRAZ, INST ORGAN CHEM, GRAZ, AUSTRIA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 30卷 / 04期

关键词：

2-ACETYLBUTYROLACTONE; PYRIDO[1,2-ALPHA]BENZIMIDAZOLE; ANTINEOPLASTIC ACTIVITY;

D O I：

10.1016/0223-5234(96)88241-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Some pyrido[1,2-a]benzimidazoles were prepared in order to investigate their in vitro antineoplastic and anti-HIV activities. Two compounds (9b, NSC 658526 and 15, NSC 664715) showed a variable degree of antineoplastic activity against some of the cell lines tested. Compound 9a (NSC 649900) exhibited a good in vitro antineoplastic activity with subpanel disease selectivity, particularly against most of the cell lines of leukemia and some cell lines from colon, melanoma and renal cancer panels.

引用

页码：327 / 332

页数：6

共 13 条

[1]

ALPERMAN.HG, 1966, ARZNEI-FORSCHUNG, V16, P1641

[2]

BADAWEY EAM, 1992, FARMACO, V47, P489

[3]

BENZIMIDAZOLE CONDENSED RING-SYSTEMS .4. NEW APPROACHES TO THE SYNTHESIS OF SUBSTITUTED PYRIMIDO[1,6-A]-BENZIMIDAZOLE-1,3(2H,5H)-DIONES [J].