INTRASTRIATAL INJECTION OF CANNABINOID RECEPTOR AGONISTS INDUCED TURNING BEHAVIOR IN MICE

被引：57

作者：

SOUILHAC, J ^{[1
]}

PONCELET, M ^{[1
]}

RINALDICARMONA, M ^{[1
]}

LEFUR, G ^{[1
]}

SOUBRIE, P ^{[1
]}

机构：

[1] SANOFI RECH,DEPT NEUROPSYCHIAT,F-34184 MONTPELLIER 04,FRANCE

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 51卷 / 01期

关键词：

CANNABINOID RECEPTOR AGONISTS; ANANDAMIDE; SR; 141716A; STRIATUM; TURNING; DOPAMINE; 6-OHDA LESIONS; MOUSE;

D O I：

10.1016/0091-3057(94)00396-Z

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

When injected unilaterally into the mouse striatum, cannabinoid agonists such as Win 55212-2 (1-100 ng/mouse), CP 55940 (0.1-50 ng/mouse), and anandamide (0.5-50 ng/mouse), the putative endogenous ligand of CB1 receptor, dose-dependently induced turning behavior. SR 141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4,-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride], the selective antagonist of CB1 receptor, antagonized the three cannabinoid receptor agonists-induced turning with similar ED(50)s (0.13-0.15 mg/kg, IP). Spiroperidol (a D-2 receptor blocker), (+)-SCH 23390 (a D-1 receptor blocker), or prior 6-OHDA lesions of the striatum blocked Win 55212-2- and CP 55940-induced turning, thus suggesting the involvement of DA transmission in cannabinoid-induced turning. Taken together, these findings reinforce the notion of a cannabinoid receptor-mediated control of nigrostriatal function.

引用

页码：3 / 7

页数：5

共 34 条

[1] CANNABINOID RECEPTOR-REGULATED CYCLIC-AMP ACCUMULATION IN THE RAT STRIATUM
BIDAUTRUSSELL, M
HOWLETT, AC
[J]. JOURNAL OF NEUROCHEMISTRY, 1991, 57 (05) : 1769 - 1773
[2] THC DOES NOT AFFECT STRIATAL DOPAMINE RELEASE - MICRODIALYSIS IN FREELY MOVING RATS
CASTANEDA, E
MOSS, DE
ODDIE, SD
WHISHAW, IQ
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 40 (03) : 587 - 591
[3] VENTRAL TEGMENTAL MICROINJECTION OF DELTA(9)-TETRAHYDROCANNABINOL ENHANCES VENTRAL TEGMENTAL SOMATODENDRITIC DOPAMINE LEVELS BUT NOT FOREBRAIN DOPAMINE LEVELS - EVIDENCE FOR LOCAL NEURAL ACTION BY MARIJUANAS PSYCHOACTIVE INGREDIENT
CHEN, JP
MARMUR, R
PULLES, A
PAREDES, W
GARDNER, EL
[J]. BRAIN RESEARCH, 1993, 621 (01) : 65 - 70
[4] EFFECTS OF ANANDAMIDE ON CANNABINOID RECEPTORS IN RAT-BRAIN MEMBRANES
CHILDERS, SR
SEXTON, T
ROY, MB
[J]. BIOCHEMICAL PHARMACOLOGY, 1994, 47 (04) : 711 - 715
[5] COMPTON DR, 1993, J PHARMACOL EXP THER, V265, P218
[6] DEVANE WA, 1988, MOL PHARMACOL, V34, P605
[7] ISOLATION AND STRUCTURE OF A BRAIN CONSTITUENT THAT BINDS TO THE CANNABINOID RECEPTOR
DEVANE, WA
HANUS, L
BREUER, A
PERTWEE, RG
STEVENSON, LA
GRIFFIN, G
GIBSON, D
MANDELBAUM, A
ETINGER, A
MECHOULAM, R
[J]. SCIENCE, 1992, 258 (5090) : 1946 - 1949
[8] IN-VITRO AND IN-VIVO BIOLOGICAL-ACTIVITIES OF SR140333, A NOVEL POTENT NONPEPTIDE TACHYKININ NK1, RECEPTOR ANTAGONIST
EMONDSALT, X
DOUTREMEPUICH, JD
HEAULME, M
NELIAT, G
SANTUCCI, V
STEINBERG, R
VILAIN, P
BICHON, D
DUCOUX, JP
PROIETTO, V
VANBROECK, D
SOUBRIE, P
LEFUR, G
BRELIERE, JC
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 250 (03) : 403 - 413
[9] FELDER CC, 1992, MOL PHARMACOL, V42, P838
[10] FACILITATION OF BRAIN-STIMULATION REWARD BY DELTA-9-TETRAHYDROCANNABINOL
GARDNER, EL
PAREDES, W
SMITH, D
DONNER, A
MILLING, C
COHEN, D
MORRISON, D
[J]. PSYCHOPHARMACOLOGY, 1988, 96 (01) : 142 - 144

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