Rakicidins, new cytotoxic lipopeptides from Micromonospora sp Fermentation, isolation and characterization

被引：87

作者：

McBrien, KD

Berry, RL

Lowe, SE

Neddermann, KM

Bursuker, I

Huang, S

Klohr, SE

Leet, JE

机构：

[1] Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Wallingford, Connecticut 06492

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 12期

关键词：

D O I：

10.7164/antibiotics.48.1446

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The new cytotoxic agents rakicidins A and B were isolated from cultured broth of a Micromonospora sp. Spectroscopic and amino acid analysis has shown that rakicidin A is a new cyclic lipopeptide, consisting of 4-amino-penta-2,4-dienoic acid. 3-hydroxy-2,4,16-trimethyl-heptadecanoic acid, sarcosine, and 3-hydroxyasparagine. Rakicidin B differs by one methylene group in the lipid side chain. These compounds exhibited cytotoxicity against the M109 cell line.

引用

页码：1446 / 1452

页数：7

共 6 条

[1]

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