High-density renal masses are atypical tensions that represent a diagnostic dilemma for computed tomography (CT). The differential diagnosis includes mainly complicated benign cysts and malignant neoplasms. This report analyzes the CT findings in 17 cases [human], of discrete, sharply marginated masses that initially exceeded the density of the uninvolved renal parenchyma, averaging .gtoreq. 50 H. The subsequently proven pathologic entities responsible for these high attenuation values included primary malignancies in 6 patients, one of whom also had multiple retention cysts containing highly proteinaceous, gelatinous material; a hemorrhagic cyst with an associated desmoplastic, fibrotic reaction in 1 patient and single or multiple hemorrhagic cysts in 4 patients. No histologic proof was obtained in 6 patients, 3 with neoplastic disease and 1 mentally retarded youth who underwent renal aspiration without sufficient material obtained for analysis. Two patients with presumed hemorrhagic cysts have had serial CT scans without interval change in 8-12 mo. An approach to the therapeutic management of affected patients is described.