CULTURED KAPOSIS SARCOMA-DERIVED CELLS EXPRESS FUNCTIONAL PDGF A-TYPE AND B-TYPE RECEPTORS

被引：38

作者：

WERNER, S ^{[1
]}

HOFSCHNEIDER, PH ^{[1
]}

HELDIN, CH ^{[1
]}

OSTMAN, A ^{[1
]}

ROTH, WK ^{[1
]}

机构：

[1] LUDWIG INST CANC RES,S-75123 UPPSALA,SWEDEN

来源：

EXPERIMENTAL CELL RESEARCH | 1990年 / 187卷 / 01期

关键词：

D O I：

10.1016/0014-4827(90)90122-Q

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have investigated the role of platelet-derived growth factor (PDGF) for the growth of cultured Kaposi's sarcoma (KS)-derived cells. They were found to bind 125I-PDGF-AA and 125I-PDGF-BB in a manner which is consistent with the presence of both PDGF A-type and PDGF B-type receptors. Furthermore, KS cells responded mitogenically to both PDGF homodimers. This shows that KS cells have functional A- and B-type PDGF receptors, suggesting an important role of PDGF for the growth of KS cells in vitro. In addition we found that KS cells produce PDGF-A chain mRNA in response to PDGF stimulation. This suggests that a PDGF-induced autocrine stimulation involving PDGF-AA which could amplify the response to PDGF occurs in these cells. © 1990.

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页码：98 / 103

页数：6

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