PANCREATIC SECRETORY RESPONSES TO LONG-TERM INFUSIONS OF SECRETIN AND CERULEIN IN HUMANS

被引：8

作者：

ADLER, G

DREWE, J

STEINMETZ, A

LIYANAGE, K

BEGLINGER, C

机构：

[1] Department of Internal Medicine, Philipps University, Marburg

[2] Division of Gastroenterology, Department of Research, University Hospital, Basel

来源：

PANCREAS | 1990年 / 5卷 / 06期

关键词：

Cerulein; Pancreatic secretion; Secretin;

D O I：

10.1097/00006676-199011000-00008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We measured pancreatic enzyme and bicarbonate responses to graded doses of intravenous secretin or cerulein alone or together in healthy human subjects. Bicarbonate responses were steady and well maintained during the last 3.5 h of the 4 h of infusions of secretagogues, giving evidence for a constant pancreatic flow rate. Potentiation (more-than-additive response) was observed between secretin and cerulein for bicarbonate secretion, but not for enzyme secretion. Secretin stimulated pancreatic enzyme secretion. The effect was most pronounced with amylase secretion and less prominent with lipase, trypsin, and chymotrypsin secretion. Changes in the proportion of enzymes were seen over time, with trypsin and chymotrypsin output declining towards the end of cerulein infusion. We conclude that in humans the effects of secretin on pancreatic enzyme secretion are complex and include time-dependent changes in the enzyme mixture, but potentiation between secretin and cerulein does not occur for enzyme output. © 1990 Raven Press, New York.

引用

页码：685 / 692

页数：8

共 32 条

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