AN IMPROVED METHOD OF INVIVO WOUND DISRUPTION AND MEASUREMENT

被引:14
作者
CHARLES, D
WILLIAMS, K
PERRY, LC
FISHER, J
REES, RS
机构
[1] RECONSTRUCT SURG FDN,NASHVILLE,TN
[2] UNIV MICHIGAN,PLAST & RECONSTRUCT SURG SECT,ANN ARBOR,MI 48109
关键词
D O I
10.1016/0022-4804(92)90076-C
中图分类号
R61 [外科手术学];
学科分类号
摘要
Biomechanical studies of wound strength are important because of new investigations in growth factors, cytokines, and fetal wounds. We compared two traditional methods of wound disruption measurement with a novel computerized model designed for in vivo experiments. An Instron tensiometer (INSTS) and an air insufflated positive pressure device (AIPPD) were compared with a vacuum-controlled wound chamber device (VCWCD). The VCWCD produced vacuum at the wound site and wound disruption was monitored with two video camera/recorders. Rats were marked with a template guide for a 2.5 cm, full-thickness, abdominal incisional wound. Rats were divided into three groups and studied at 2, 7, or 14 days after wounding. The recorded images were computer digitalized to generate wound strength curves from a three-dimensional model. A comparison of the wound disruption curves demonstrated that the VCWCD was comparable to the INST or AIPPD in normal wound healing (P > .40). The VCWCD provided data with less standard error at 2 days after wounding (P < 05). In separate series of experiments, VCWCD was tested in the early phases of healing and was found to be sensitive to change at intervals of 48 hr after wounding (P < .005). The INST or AIPPD methods could not perform this task because of an unacceptable level of random error after tissue manipulation. The VCWCD system was considered superior for evaluating early wound healing because it was an in vivo method which required minimal wound manipulation. © 1992.
引用
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页码:214 / 218
页数:5
相关论文
共 12 条
  • [1] ACCELERATION OF TENSILE-STRENGTH OF INCISIONS TREATED WITH EGF AND TGF-BETA
    BROWN, GL
    CURTSINGER, LJ
    WHITE, M
    MITCHELL, RO
    PIETSCH, J
    NORDQUIST, R
    VONFRAUNHOFER, A
    SCHULTZ, GS
    [J]. ANNALS OF SURGERY, 1988, 208 (06) : 788 - 794
  • [2] ENHANCEMENT OF WOUND-HEALING BY TOPICAL TREATMENT WITH EPIDERMAL GROWTH-FACTOR
    BROWN, GL
    NANNEY, LB
    GRIFFEN, J
    CRAMER, AB
    YANCEY, JM
    CURTSINGER, LJ
    HOLTZIN, L
    SCHULTZ, GS
    JURKIEWICZ, MJ
    LYNCH, JB
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (02) : 76 - 79
  • [3] Cahill B P, 1987, Biomed Sci Instrum, V23, P29
  • [4] EXPERIMENTAL-METHOD FOR DETERMINING 2-DIMENSIONAL MECHANICAL-PROPERTIES OF LIVING HUMAN-SKIN
    COOK, T
    ALEXANDER, H
    COHEN, M
    [J]. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1977, 15 (04) : 381 - 390
  • [5] CRAWFORD DT, 1965, J SURG RES, V6, P265
  • [6] FETAL RESPONSE TO INJURY IN THE RABBIT
    KRUMMEL, TM
    NELSON, JM
    DIEGELMANN, RF
    LINDBLAD, WJ
    SALZBERG, AM
    GREENFIELD, LJ
    COHEN, IK
    [J]. JOURNAL OF PEDIATRIC SURGERY, 1987, 22 (07) : 640 - 644
  • [7] TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA) INDUCES FIBROSIS IN A FETAL WOUND MODEL
    KRUMMEL, TM
    MICHNA, BA
    THOMAS, BL
    SPORN, MB
    NELSON, JM
    SALZBERG, AM
    COHEN, IK
    DIEGELMANN, RF
    [J]. JOURNAL OF PEDIATRIC SURGERY, 1988, 23 (07) : 647 - 652
  • [8] FAILURE PROPERTIES OF PASSIVE HUMAN AORTIC TISSUE .2. BIAXIAL TENSION TESTS
    MOHAN, D
    MELVIN, JW
    [J]. JOURNAL OF BIOMECHANICS, 1983, 16 (01) : 31 - +
  • [9] ACCELERATED HEALING OF INCISIONAL WOUNDS IN RATS INDUCED BY TRANSFORMING GROWTH-FACTOR-BETA
    MUSTOE, TA
    PIERCE, GF
    THOMASON, A
    GRAMATES, P
    SPORN, MB
    DEUEL, TF
    [J]. SCIENCE, 1987, 237 (4820) : 1333 - 1336
  • [10] MYERS MB, 1967, ARCH SURG-CHICAGO, V94, P218