EVALUATION OF THE GENOTOXIC POTENTIAL OF ALKYLENEAMINES

被引:20
作者
LEUNG, HW
机构
[1] Applied Toxicology, Union Carbide Corporation, Danbury, CT 06817
来源
MUTATION RESEARCH | 1994年 / 320卷 / 1-2期
关键词
ALKYLENEAMINES; AMES SALMONELLA ASSAY; CHINESE HAMSTER OVARY CELL GENE-MUTATION ASSAY; SISTER-CHROMATID EXCHANGE ASSAY; MICRONUCLEUS TEST; MOUSE;
D O I
10.1016/0165-1218(94)90057-4
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A series of 6 alkyreneamines [ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetramine (TETA), tetraethylenepentamine (TEPA), aminoethylethanolamine (AEEA), and aminoethylpiperazine (AEP)I were evaluated for potential genotoxic activity using a battery of in vitro and in vivo assays. Only TETA was considered mutagenic in the Salmonella typhimurium mutation assay. Ail 6 alkyleneamines tested except AEP were considered inactive in the Chinese hamster ovary (CHO) gene mutation assay. AEP was considered inconclusive in this assay. In 2 the sister-chromatid exchange (SCE) assay, EDA, DETA and AEEA were inactive with or without metabolic activation. TETA, TEPA and AEP were considered active in the induction of SCE in CHO cells. With hepatocytes, no positive effects of EDA, DETA AEEA and AEP upon unscheduled DNA syntheses (UDS) were noted. However, TETA and TEPA produced significant increases in the amount of UDS activity, and thus were considered positive in inducing primary DNA damage in this assay. In a micronucleus study with Swiss-Webster mice, no clastogenic activity was observed with TETA, TEPA and AEP. The overall weight of evidence from the in vitro and in vivo tests suggested that EDA, DETA and AEEA were not mutagenic, while TETA was mutagenic, and TEPA and AEP had a weak mutagenic potential.
引用
收藏
页码:31 / 43
页数:13
相关论文
共 26 条
[1]   METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].
AMES, BN ;
MCCANN, J ;
YAMASAKI, E .
MUTATION RESEARCH, 1975, 31 (06) :347-363
[2]   DERMAL ONCOGENICITY STUDIES ON VARIOUS ETHYLENEAMINES IN MALE C3H MICE [J].
DEPASS, LR ;
FOWLER, EH ;
WEIL, CS .
FUNDAMENTAL AND APPLIED TOXICOLOGY, 1987, 9 (04) :807-811
[3]   DERMAL ONCOGENICITY STUDIES ON ETHYLENEDIAMINE IN MALE C3H MICE [J].
DEPASS, LR ;
FOWLER, EH ;
YANG, RSH .
FUNDAMENTAL AND APPLIED TOXICOLOGY, 1984, 4 (04) :641-645
[4]  
DESERRES FD, 1974, MUTAT RES, V64, P159
[5]  
GALLAPUDI BB, 1974, MUTAT RES, V64, P45
[6]  
GALLUPUDI BB, 1988, EVALUATION DIETHYLEN
[7]   SALMONELLA MUTAGENICITY TEST-RESULTS FOR 250 CHEMICALS [J].
HAWORTH, S ;
LAWLOR, T ;
MORTELMANS, K ;
SPECK, W ;
ZEIGER, E .
ENVIRONMENTAL MUTAGENESIS, 1983, 5 :3-&
[8]   THE INDUCTION OF MICRONUCLEI AS A MEASURE OF GENOTOXICITY - A REPORT OF THE UNITED-STATES ENVIRONMENTAL-PROTECTION-AGENCY GENE-TOX PROGRAM [J].
HEDDLE, JA ;
HITE, M ;
KIRKHART, B ;
MAVOURNIN, K ;
MACGREGOR, JT ;
NEWELL, GW ;
SALAMONE, MF .
MUTATION RESEARCH, 1983, 123 (01) :61-118
[9]  
HEDENSTEDT A, 1978, MUTAT RES, V53, P198, DOI 10.1016/0165-1161(78)90235-2
[10]  
HEINZ N, 1981, ARZNEIMITTEL-FORSCH, V31-1, P950