A COMPARATIVE-STUDY ON DEFENSE SYSTEMS FOR LIPID-PEROXIDATION BY FREE-RADICALS IN SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RAT MYOCARDIUM

被引：42

作者：

ITO, H

TORII, M

SUZUKI, T

机构：

[1] Department of Pathology, Kinki University School of Medicine, Osaka, 589, 377-2 Ohno-higashi, Osaka-sayama

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1992年 / 103卷 / 01期

关键词：

D O I：

10.1016/0305-0491(92)90410-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Antiperoxidation ability and lipid peroxidation in myocardium were examined in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) at 6 and 16 weeks of age. 2. Glutathione peroxidase activity was higher in SHR at 6 weeks of age, but lower at 16 weeks compared to that in WKY. Alpha-Tocopherol content was lower in SHR at both 6 and 16 weeks of age than in WKY. 3. In vitro formation of free malondialdehyde was more pronounced in SHR myocardium than in WKY. 4. Coincidence of lower antiperoxidation ability and higher peroxidation of membrane phospholipid indicate myocardial cell vulnerability in SHR hypertrophied myocardium.

引用

页码：37 / 40

页数：4

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