MULTIPLE ALLELIC LOSSES IN SARCOMATOID LIVER-CARCINOMA

被引：3

作者：

DING, SF

CARRILLO, A

DOOLEY, JS

DELHANTY, JDA

BOWLES, L

DALLASERRA, G

WOOD, CB

HABIB, NA

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT SURG,DUCANE RD,LONDON W12 0NN,ENGLAND

[2] UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT SURG,LONDON,ENGLAND

[3] UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT MED,LONDON,ENGLAND

[4] UNIV LONDON UNIV COLL,DEPT GENET & BIOMETRY,LONDON WC1E 6BT,ENGLAND

来源：

INTERNATIONAL HEPATOLOGY COMMUNICATIONS | 1993年 / 1卷 / 06期

关键词：

CARCINOMA; TUMOR; SARCOMATOID; DNA; MOLECULAR GENETICS; LIVER;

D O I：

10.1016/0928-4346(93)90001-V

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Sarcomatoid carcinoma is an uncommon variant of carcinoma. There has been no molecular-genetic study on this type of tumour as yet. Here we report the first study of chromosome allele loss in two patients with sarcomatoid liver carcinoma. Twenty-five DNA restriction fragment length polymorphism probes were used, of which sixteen revealed informative patterns in each of the patient's normal DNA. One of the patients had allelic losses shown by ten probes and a rearrangement detected by one probe in her tumour DNA. The second patient had eight allelic losses in her tumour. In summary, both tumours revealed multiple genetic changes.

引用

页码：295 / 301

页数：7

共 19 条

[1] LOSS OF HETEROZYGOSITY SUGGESTS TUMOR SUPPRESSOR GENE RESPONSIBLE FOR PRIMARY HEPATOCELLULAR-CARCINOMA [J].

BUETOW, KH ;

MURRAY, JC ;

ISRAEL, JL ;

LONDON, WT ;

SMITH, M ;

KEW, M ;

BLANQUET, V ;

BRECHOT, C ;

REDEKER, A ;

GOVINDARAJAH, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8852-8856

[2] LOSS OF HETEROZYGOSITY ON CHROMOSOME-1 AND CHROMOSOME-11 IN CARCINOMA OF THE PANCREAS [J].

DING, SF ;

HABIB, NA ;

DELHANTY, JDA ;

BOWLES, L ;

GRECO, L ;

WOOD, C ;

WILLIAMSON, RCN ;

DOOLEY, JS .

BRITISH JOURNAL OF CANCER, 1992, 65 (06) :809-812

[3] LOSS OF CONSTITUTIONAL HETEROZYGOSITY ON CHROMOSOME-5Q IN HEPATOCELLULAR-CARCINOMA WITHOUT CIRRHOSIS [J].

DING, SF ;

HABIB, NA ;

DOOLEY, J ;

WOOD, C ;

BOWLES, L ;

DELHANTY, JDA .

BRITISH JOURNAL OF CANCER, 1991, 64 (06) :1083-1087

[4]

DING SF, 1992, BRIT J CANCER, V67, P244

[5]

FUJIMORI M, 1991, CANCER RES, V51, P89

[6]

HARATAKE J, 1991, CANCER, V68, P93, DOI 10.1002/1097-0142(19910701)68:1<93::AID-CNCR2820680119>3.0.CO

[7]

2-G

[8]

KAKIZOE S, 1987, CANCER-AM CANCER SOC, V59, P310, DOI 10.1002/1097-0142(19870115)59:2<310::AID-CNCR2820590224>3.0.CO

[9]

2-S

[10] LOSS OF CONSTITUTIONAL HETEROZYGOSITY IN HUMAN CANCER [J].

LASKO, D ;

CAVENEE, W ;

NORDENSKJOLD, M .

ANNUAL REVIEW OF GENETICS, 1991, 25 :281-314

← 1 2 →