STAT3 AND STAT4 - MEMBERS OF THE FAMILY OF SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION

被引：364

作者：

ZHONG, Z ^{[1
]}

WEN, ZL ^{[1
]}

DARNELL, JE ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,MOLEC CELL BIOL LAB,NEW YORK,NY 10021

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 11期

关键词：

TRANSCRIPTION FACTORS;

D O I：

10.1073/pnas.91.11.4806

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The deduced amino acid sequence of two members of the signal transducers and activators of transcription (STAT) family from the mouse are described. Comparison with the deduced protein sequence of the two previously described genes (Stat91 and Stat113), discovered because of their activation as transcription factors after interferon-induced tyrosine phosphorylation, shows several highly conserved regions, including the putative SH3 and SH2 domains. The conserved amino acid stretches likely point to conserved domains that enable these proteins to carry out the several required functions they are known and proposed to carry out. While Stat1 and Stat3 are widely expressed, Stat4 expression is restricted to testis, thymus, and spleen. Antiserum to Stat3 detects a major approximate to 92-kDa protein and a minor approximate to 89-kDa protein, while antiserum to Stat4 precipitates one major protein of approximate to 89-kDa.

引用

页码：4806 / 4810

页数：5

共 29 条

[1] CHARACTERIZATION OF A PATHWAY FOR CILIARY NEUROTROPHIC FACTOR SIGNALING TO THE NUCLEUS [J].