NON-INSULIN-DEPENDENT DIABETES-MELLITUS COMPLICATED WITH IDIOPATHIC HYPOPARATHYROIDISM

被引:3
作者
ITOH, H [1 ]
MATSUDA, Y [1 ]
NISHIYAMA, M [1 ]
KITAGAWA, T [1 ]
KOBAYASHI, T [1 ]
NIO, Y [1 ]
HAMA, S [1 ]
HOSOGI, H [1 ]
HIROI, T [1 ]
HASHIMOTO, K [1 ]
机构
[1] KOCHI MED SCH,DEPT INTERNAL MED,KOCHI 783,JAPAN
关键词
HYPOCALCEMIA; INSULIN SECRETION; OCULOMOTOR NERVE PALSY;
D O I
10.2169/internalmedicine.34.904
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report a case of non-insulin-dependent diabetes mellitus (NIDDM) complicated with idiopathic hypoparathyroidism. A 74-year-old male was hospitalized because of diplopia, He was revealed to have NIDDM, The levels of serum Ca and intact-PTH were 6.3 mg/dl and < 5 pg/ml, respectively, Brain computed tomography revealed abnormal calcification in the cerebral basal ganglia and the cerebellum, After recovery from hypocalcemia, the endogenous insulin secretion was normalized, It is suggested that the pathogenesis of NIDDM in this patient may have been related to an insulin secretory defect as a result of hypocalcemia in addition to the hereditary risk.
引用
收藏
页码:904 / 907
页数:4
相关论文
共 13 条
[1]  
Neufeld M., Maclaren N., Blizzard R., Autoimmune polyglandular syndrome, Pediatr Ann, 9, (1980)
[2]  
Shigemasa C., Tanaka T., Yoshida A., Okamura Y., Mashiba H., Abe K., A case of idiopathic hypoparathyroidism showed improvement of hypocalcemia and insulin secretion with administration of 1α-hydroxycholecalciferol, Naika, 47, (1981)
[3]  
Akasu F., Haraguchi K., Tsunoda S., Shiozawa Z., Onaya T., Hypoparathyroidism associated with ossification of posterior longitudinal ligament of the spine (OPLL) and glucose intolerance - report of two cases, Naika, 57, (1986)
[4]  
Takeda H., Miyano R., Machimura H., Et al., An autopsy case of idiopathic hypoparathyroidism with diabetes mellitus, Hormone To Rinsho, 39, (1991)
[5]  
Yasuda K., Hurukawa Y., Okuyama M., Kikuchi M., Yoshinaga K., Glucose tolerance and insulin secretion in patients with parathyroid disorders, N Engl J Med, 292, (1975)
[6]  
Hellman B., The significance of calcium for glucose stimulation of insulin release, Endocrinology, 97, (1975)
[7]  
Bergsten P., Hellman B., Glucose inhibits insulinrelease when not promoting the entry of calcium into the β-cells, Biochem Biophys Res Commun, 125, (1984)
[8]  
Bergsten P., Grapengiesser E., Gylfe E., Tengholm A., Hellman B., Synchronous oscillations of cytoplasmic Ca2+ and insulin release in glucosestimulated pancreatic islets, J Biol Chem, 269, (1994)
[9]  
Ikeda T., Kurahashi A., Shigemasa C., Et al., Insulin and glucagon secretion in a case of idiopathic hypoparathyroidism, J Jpn Diabetes Soc, 24, (1981)
[10]  
Johnson J.A., Grandle J.P., Roche P.C., Kumar R., Immunohistochemical localization of the 1.25(OH)2D3 receptor and calbindin D28k in human and rat pancreas, Am J Physiol, 267, (1994)