EFFECT OF ACUTE AND REPEATED EXPOSURE TO LOW-DOSES OF HYDRAZINE ON HEPATIC-MICROSOMAL ENZYMES AND BIOCHEMICAL PARAMETERS IN-VIVO

被引：18

作者：

JENNER, AM ^{[1
]}

TIMBRELL, JA ^{[1
]}

机构：

[1] UNIV LONDON,SCH PHARM,DEPT TOXICOL,LONDON WC1N 1AX,ENGLAND

来源：

ARCHIVES OF TOXICOLOGY | 1994年 / 68卷 / 04期

关键词：

HYDRAZINE; LIVER; MICROSOMAL ENZYMES; CYP2E1; RAT;

D O I：

10.1007/s002040050063

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A single dose of hydrazine (3 mg.kg(-1) i.p.) caused hepatic accumulation of triglycerides and depletion of ATP in rats after 9 h. Repeated exposure of rats to hydrazine (congruent to 2.5 mg.kg(-1) per day) for 10 days resulted in depletion of hepatic reduced glutathione (GSH) and triglycerides. Repeated exposure to hydrazine also caused a significant (time dependent) induction of p-nitrophenol hydroxylase (NPH) activity together with changes in other hepatic microsomal enzymes. These included 7-pentoxyresorufin O-deethylase (PROD) and 7-ethoxyresorufin O-de ethylase (EROD) activity, total cytochrome P450, cytochrome b(5) and cytochrome P450 reductase activity. Repeated exposure to lower levels of hydrazine (congruent to 0.250 mg.kg(-1) per day) caused no significant hepatic biochemical or microsomal changes after 5 or 10 days except for an increase in NPH activity (17%) and liver ATP (15%) after 5 days.

引用

页码：240 / 245

页数：6

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