CYTOKINE REGULATION OF GRANULOMA-FORMATION IN SCHISTOSOMIASIS

被引：139

作者：

WYNN, TA ^{[1
]}

CHEEVER, AW ^{[1
]}

机构：

[1] NIAID,PARASIT DIS LAB,HOST PARASITE RELAT SECT,BETHESDA,MD 20892

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 04期

关键词：

D O I：

10.1016/0952-7915(95)80095-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Granuloma induced by the schistosome egg is an inflammatory reaction that is tightly controlled by the interaction of T-helper cell type 1 (Th1) and Th2 cytokines produced locally. Studies focussing on the immunoregulation of the response have yielded numerous insights into the cytokine cascade that controls the formation of the lesions. It is dear from current data that the Th2 cytokines play a primary role in granuloma formation, whereas the Th1-associated lymphokine interferon-gamma acts as an endogenous down regulator of the response. Through recent advances, it may now be possible to design effective cytokine-based vaccination strategies that will suppress the tissue pathology associated with this helminth infection.

引用

页码：505 / 511

页数：7

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