HEPATOCYTE SWELLING INCREASES INOSITOL 1,4,5-TRISPHOSPHATE, CALCIUM AND CYCLIC-AMP CONCENTRATION BUT ANTAGONIZES PHOSPHORYLASE ACTIVATION BY CA-2+-DEPENDENT HORMONES

被引：46

作者：

BAQUET, A

MEIJER, AJ

HUE, L

机构：

[1] CATHOLIC UNIV LOUVAIN,ICP 7529,INT INST CELLULAR & MOLEC PATHOL,AVE HIPPOCRATE 75,B-1200 BRUSSELS,BELGIUM

[2] CATHOLIC UNIV LOUVAIN,SCH MED,HORMONE & METAB RES UNIT,B-1200 BRUSSELS,BELGIUM

[3] UNIV AMSTERDAM,ACAD MED CTR,EC SLATER INST BIOCHEM RES,1105 AZ AMSTERDAM,NETHERLANDS

来源：

FEBS LETTERS | 1991年 / 278卷 / 01期

关键词：

CALCIUM; CAMP; HEPATOCYTE; PHOSPHORYLASE; VASOPRESSIN; SWELLING;

D O I：

10.1016/0014-5793(91)80094-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Swelling of hepatocytes increases the concentration of inositol 1,4,5-trisphosphate, Ca2+ and cAMP, without activating glycogen phosphorylase. In these hepatocytes, the activation of phosphorylase by suboptimal concentrations of vasopressin or angiotensin II was partly antagonized.

引用

页码：103 / 106

页数：4

共 16 条

[1]

BAQUET A, 1990, J BIOL CHEM, V265, P955

[2] INOSITOL PHOSPHATES AND CELL SIGNALING [J].