CHROMOGENIC DEPSIPEPTIDE SUBSTRATES FOR BETA-LACTAMASES AND PENICILLIN-SENSITIVE DD-PEPTIDASES

被引：99

作者：

ADAM, M

DAMBLON, C

PLAITIN, B

CHRISTIAENS, L

FRERE, JM

机构：

[1] UNIV LIEGE,INST CHIM,ENZYMOL LAB,B6,B-4000 LIEGE,BELGIUM

[2] UNIV LIEGE,INST CHIM,SERV CHIM ORGAN,B-4000 LIEGE,BELGIUM

来源：

BIOCHEMICAL JOURNAL | 1990年 / 270卷 / 02期

关键词：

D O I：

10.1042/bj2700525

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various ester and thioester derivatives of hippuric acid have been prepared which were substrates of both β-lactamases and DD-peptidases. The thioesters were more rapidly hydrolysed by nearly all the enzymes. Surprisingly, the enzymes acted rather efficiently on substrates which did not contain any chiral centre.

引用

收藏

页码：525 / 529

页数：5

相关论文

共 18 条

[1] USE OF ESTERS OF N-HYDROXYSUCCINIMIDE IN PEPTIDE SYNTHESIS [J].

ANDERSON, GW ;

CALLAHAN, FM ;

ZIMMERMAN, JE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (09) :1839-+

[2] A NEW METHOD FOR THE PREPARATION OF TERTIARY BUTYL ETHERS AND ESTERS [J].

ARMSTRONG, A ;

BRACKENRIDGE, I ;

JACKSON, RFW ;

KIRK, JM .

TETRAHEDRON LETTERS, 1988, 29 (20) :2483-2486

[3]

BROOK MA, 1983, SYNTHESIS-STUTTGART, P201

[4] NUCLEAR ANALOGS OF BETA-LACTAM ANTIBIOTICS .2. TOTAL SYNTHESIS OF 8-OXO-4-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACIDS [J].

BRYAN, DB ;

HALL, RF ;

HOLDEN, KG ;

HUFFMAN, WF ;

GLEASON, JG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (07) :2353-2355

[5]

CHANDRIKA P, 1987, BIOCHEMISTRY-US, V26, P3385

[6] AUTOMATED-ANALYSIS OF ENZYME INACTIVATION PHENOMENA - APPLICATION TO BETA-LACTAMASES AND DD-PEPTIDASES [J].

DEMEESTER, F ;

JORIS, B ;

RECKINGER, G ;

BELLEFROIDBOURGUIGNON, C ;

FRERE, JM ;

WALEY, SG .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (14) :2393-2403

[7] EXOCELLULAR DD-CARBOXYPEPTIDASE-ENDOPEPTIDASE FROM STREPTOMYCES-ALBUS G - PURIFICATION AND CHEMICAL PROPERTIES [J].

DUEZ, C ;

FRERE, JM ;

GEURTS, F ;

GHUYSEN, JM ;

DIERICKX, L ;

DELCAMBE, L .

BIOCHEMICAL JOURNAL, 1978, 175 (03) :793-800

[8] INTERACTIONS OF CEPHALOSPORINS WITH THE STREPTOMYCES R61 DD-TRANSPEPTIDASE CARBOXYPEPTIDASE - INFLUENCE OF THE 3'-SUBSTITUENT [J].

FARACI, WS ;

PRATT, RF .

BIOCHEMICAL JOURNAL, 1986, 238 (01) :309-312

[9] LARGE-SCALE PREPARATION OF PURIFIED EXOCELLULAR DD-CARBOXYPEPTIDASE-TRANSPEPTIDASE OF STREPTOMYCES STRAIN-R61 [J].

FOSSATI, P ;

SAINTGHISLAIN, M ;

SICARD, PJ ;

FRERE, JM ;

DUSART, J ;

KLEIN, D ;

GHUYSEN, JM .

BIOTECHNOLOGY AND BIOENGINEERING, 1978, 20 (04) :577-587

[10]

Frere J M, 1976, Methods Enzymol, V45, P610