EVOLUTION OF THE MHC CLASS-I GENES OF A NEW-WORLD PRIMATE FROM ANCESTRAL HOMOLOGS OF HUMAN NONCLASSICAL GENES

被引:143
作者
WATKINS, DI
CHEN, ZW
HUGHES, AL
EVANS, MG
TEDDER, TF
LETVIN, NL
机构
[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115
[2] UNIV TEXAS,HLTH SCI CTR,CTR DEMOG & POPULAT GENET,HOUSTON,TX 77225
关键词
D O I
10.1038/346060a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
THE products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes1-4. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements for the majority of T lymphocytes5-7. The evolutionary relationship of the non-classical and classical MHC class I genes is unclear. Here we present the cloning and sequencing of the MHC class I genes of a New World primate, the cotton-top tamarin (Saguinus oedipus). The expressed MHC class I genes of this species are more closely related to the human non-classical HLA-G (ref. 7) gene than they are to genes of the human classical HLA-A, -B, and -C loci. These observations imply that classical and non-classical genes do not necessarily constitute mutually exclusive groups over evolutionary time. © 1990 Nature Publishing Group.
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页码:60 / 63
页数:4
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