CEREBRAL-CORTEX AND LUNG INDOLEAMINE-2,3-DIOXYGENASE ACTIVITY IS INCREASED IN TYPE-D RETROVIRUS INFECTED MACAQUES

被引:50
作者
SAITO, K
LACKNER, A
MARKEY, SP
HEYES, MP
机构
[1] NIMH, CLIN SCI LAB,ANALYT BIOCHEM LAB,BLDG 10,ROOM 3D40, BETHESDA, MD 20892 USA
[2] UNIV CALIF DAVIS, CALIF REG PRIMATE RES CTR, DAVIS, CA 95616 USA
关键词
INDOLEAMINE-2,3-DIOXYGENASE; CEREBRAL CORTEX; LUNG; EXCITOTOXIN; TYPE-D RETROVIRUS; SIMIAN ACQUIRED IMMUNE DEFICIENCY SYNDROME; KYNURENINE PATHWAY;
D O I
10.1016/0006-8993(91)90536-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Increased concentrations of the neuroactive kynurenine pathway metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA), occur in the CSF of humans infected with the human immunodeficiency virus and macaques infected with retroviruses, including the D/1/ California serotype. In the present study, increased activity of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, occurred in cerebral cortex and lung of macaques with clinical SAIDS. Such increases provide a mechanism to accelerate the formation of kynurenine pathway metabolites in both systemic tissues and the central nervous system.
引用
收藏
页码:353 / 356
页数:4
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