GENETIC INSTABILITY OF MICROSATELLITE MARKERS IN REGION-Q22.3-Q31 OF CHROMOSOME-9 IN SKIN SQUAMOUS-CELL CARCINOMAS

被引：18

作者：

ZAPHIROPOULOS, PG

SODERKVIST, P

HEDBLAD, MA

TOFTGARD, R

机构：

[1] LINKOPING UNIV HOSP, FAC HLTH SCI, DEPT OCCUPAT & ENVIRONM MED, S-58185 LINKOPING, SWEDEN

[2] KAROLINSKA HOSP, DEPT DERMATOL, S-10401 STOCKHOLM, SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.1873

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microsatellite markers assigned to chromosome 9q22.3-q31 were used in order to analyze squamous cell carcinomas from human skin. From the informative samples examined, one showed loss of heterozygosity with both microsatellite markers D9S109 and D9S180. Furthermore, in four cases with D9S109 and in one case with both microsatellite markers, genetic instability was observed in the tumors. These results are interpreted as suggestive of two distinct genetic changes associated with skin squamous cell carcinomas: Loss of a tumors suppressor gene that might relate to the observed frequent loss of a co-localized gene in basal cell carcinomas and alteration of replication/mismatch-repair factors, in similarity to the ones thought to be involved in the genetic instability detected in hereditary nonpolyposis colorectal cancer. (C) 1994 Academic Press, Inc.

引用

页码：1495 / 1501

页数：7

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