NEONATAL ADENOVIRUS INFECTION - A CASE-REPORT WITH IN-SITU HYBRIDIZATION CONFIRMATION OF ASCENDING INTRAUTERINE INFECTION

被引：17

作者：

MONTONE, KT

FURTH, EE

PIETRA, GG

GUPTA, PK

机构：

[1] Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

来源：

DIAGNOSTIC CYTOPATHOLOGY | 1995年 / 12卷 / 04期

关键词：

ADENOVIRUS INFECTION; IN-SITU HYBRIDIZATION; OLIGONUCLEOTIDES; PREGNANCY; CERVICAL SMEAR;

D O I：

10.1002/dc.2840120411

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Adenovirus infection is a rare, but serious infection, during the neonatal period. The actual mode of infection at birth is currently unknown, however several mechanisms have been proposed. We describe a case of fatal neonatal adenovirus pneumonia in a 25-wk gestational age infant. Adenovirus was confirmed by electron microscopy and by in situ hybridization. The maternal cervical/endocervical smear taken prior to the delivery contained epithelial cells with changes suggestive of adenovirus, which was confirmed by in situ hybridization on the smear. These findings suggest that ascending viral infection is a factor in the pathogenesis of neonatal adenovirus infection. The identification and reporting of adenovirus may be important during pregnancy in order to avoid delay in delivery of the fetus once membranes have ruptured. Diagn Cytopathol 1995;12:341-344. (C) 1995 Wiley-Liss, Inc.

引用

页码：341 / 344

页数：4

共 11 条

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