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CELL-CYCLE REGULATION OF THE CYCLIN-A GENE PROMOTER IS MEDIATED BY A VARIANT E2F SITE
被引：324
作者：
SCHULZE, A
ZERFASS, K
SPITKOVSKY, D
MIDDENDORP, S
BERGES, J
HELIN, K
JANSENDURR, P
HENGLEIN, B
机构：
[1] INST CURIE,CNRS,UNITE MIXTE RECH 144,F-75005 PARIS,FRANCE
[2] DEUTSCH KREBSFORSCHUNGSZENTRUM,ABT 620,D-69120 HEIDELBERG,GERMANY
[3] DANISH CANC SOC,DIV CANC BIOL,DK-2100 COPENHAGEN,DENMARK
来源：
关键词：
CYCLIN D1;
CDK4;
P16(INK4);
D O I：
10.1073/pnas.92.24.11264
中图分类号：
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号：
07 ;
0710 ;
09 ;
摘要：
Cyclin A is involved in the control of S phase and mitosis in mammalian cells, Expression of the cyclin A gene in nontransformed cells is characterized by repression of its promoter during the G(1) phase of the cell cycle and its induction at S-phase entry. We show that this mode of regulation is mediated by the transcription factor E2F, which binds to a specific site in the cyclin A promoter. It differs from the prototype E2F site in nucleotide sequence and protein binding; it is bound by E2F complexes containing cyclin E and p107 but not pRB. Ectopic expression of cyclin D1 triggers premature activation of the cyclin A promoter by E2F, and this effect is blocked by the tumor suppressor protein p16(INK4).
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页码：11264 / 11268
页数：5
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