Comparison of Toxic and Transforming Effects of Ten Environment-related Polycyclic Hydrocarbons, including Benzo [a] pyrene, on Fetal Hamster Lung Cell Cultures?

被引：10

作者：

Emura, M. ^{[1
]}

Richter-Reichhelm, H. -B. ^{[1
]}

Schneider, P. ^{[1
]}

Schoch, C. ^{[1
]}

Mohr, U. ^{[1
]}

机构：

[1] Med Hsch Hannover, Abt Expt Pathol, Karl Wiechert Allee 9, D-3000 Hannover 61, Germany

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1982年 / 2卷 / 03期

关键词：

PAH's; toxicity; transformation;

D O I：

10.1002/jat.2550020310

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Standardized procedures were developed to compare quantitatively the toxic and transforming effects of ten environment-related polycyclic aromatic hydrocarbons (PAH's) using early passage mixed cultures of fetal Syrian golden hamster lung cells. Evaluation of toxicity was attempted by applying a linear regression to the relative number of surviving colonies. Transformation data were fitted satisfactorily to the one-hit model. Used as a monitor compound in each subexperiment, benzo[a] pyrene (BaP) showed dose-related colony reduction (0.01-0.5 pg ml-I). Benzo[b] fluoranthene (BbF), indeno[1,2,3-cd] pyrene (IcdP), benzw [k] fluoranthene (BkF) and benzo[e] pyrene (BeP) were generally colony enhancing at dose ranges up to 1.0 pg ml-'. Fluoranthene (FLT), pyrene (PYR), chrysene (CHR), benzo[ghi] perylene (BghiPL) and benz[a] anthracene (BaA) were neither stimulatory nor inhibitory to colony formation. For transformation induction, BaP was over 14-fold more effective than BbF, IcdP or BaA. The other PAH's showed no transformation.

引用

页码：167 / 171

页数：5

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