Comparison of Toxic and Transforming Effects of Ten Environment-related Polycyclic Hydrocarbons, including Benzo [a] pyrene, on Fetal Hamster Lung Cell Cultures?

被引:10
作者
Emura, M. [1 ]
Richter-Reichhelm, H. -B. [1 ]
Schneider, P. [1 ]
Schoch, C. [1 ]
Mohr, U. [1 ]
机构
[1] Med Hsch Hannover, Abt Expt Pathol, Karl Wiechert Allee 9, D-3000 Hannover 61, Germany
关键词
PAH's; toxicity; transformation;
D O I
10.1002/jat.2550020310
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Standardized procedures were developed to compare quantitatively the toxic and transforming effects of ten environment-related polycyclic aromatic hydrocarbons (PAH's) using early passage mixed cultures of fetal Syrian golden hamster lung cells. Evaluation of toxicity was attempted by applying a linear regression to the relative number of surviving colonies. Transformation data were fitted satisfactorily to the one-hit model. Used as a monitor compound in each subexperiment, benzo[a] pyrene (BaP) showed dose-related colony reduction (0.01-0.5 pg ml-I). Benzo[b] fluoranthene (BbF), indeno[1,2,3-cd] pyrene (IcdP), benzw [k] fluoranthene (BkF) and benzo[e] pyrene (BeP) were generally colony enhancing at dose ranges up to 1.0 pg ml-'. Fluoranthene (FLT), pyrene (PYR), chrysene (CHR), benzo[ghi] perylene (BghiPL) and benz[a] anthracene (BaA) were neither stimulatory nor inhibitory to colony formation. For transformation induction, BaP was over 14-fold more effective than BbF, IcdP or BaA. The other PAH's showed no transformation.
引用
收藏
页码:167 / 171
页数:5
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