ENDOTOXIN REMOVAL FROM LARGE-VOLUME PARENTERALS BY VARIOUS ADSORBENTS

被引：4

作者：

BAGGERMAN, C

LOOS, JA

JUNGINGER, HE

机构：

[1] CANISIUS WILHELMINA HOSP, NIJMEGEN, NETHERLANDS

[2] LEIDEN STATE UNIV, CTR BIOPHARMACEUT SCI, 2312 AV LEIDEN, NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1985年 / 27卷 / 01期

关键词：

D O I：

10.1016/0378-5173(85)90181-4

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

To perform endotoxin-adsorption studies, the suitability of 51Cr-labelled endotoxins for this purpose was investigated. These labelled endotoxins did not exhibit important changes in physicochemical, biochemical or biological properties; in particular the adsorption behaviour of labelled and unlabelled endotoxins has been found to be identical. The adsorption of endotoxins from Large-Volume Parenterals using various adsorbents differs with respect to the solution being studied. These differences appear to result from shifts in electrokinetic forces between adsorbent and endotoxin, since the inhibiting effect of cations on endotoxin adsorption increases with increasing valency. These results suggest that the negative zetapotential of endotoxins is increased by cations according to the Schulze-Hardy rule, resulting in a different adsorption behaviour.

引用

页码：17 / 27

页数：11

共 26 条

[1]

A COMPARATIVE-STUDY ON THE PERFORMANCE OF ASBESTOS-FREE DEPTH-FILTERS FOR REMOVAL OF PYROGENS FROM INFUSION FLUIDS [J].