SELECTIVE THROMBOXANE SYNTHETASE INHIBITORS .1. 1-[(ARYLOXY)ALKYL]-1H-IMIDAZOLES

被引:56
作者
CROSS, PE [1 ]
DICKINSON, RP [1 ]
PARRY, MJ [1 ]
RANDALL, MJ [1 ]
机构
[1] PFIZER CENT RES,SANDWICH CT13 9NJ,KENT,ENGLAND
关键词
D O I
10.1021/jm00148a009
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1427 / 1432
页数:6
相关论文
共 32 条
[1]  
BLACK ML, 1970, Patent No. 3534061
[2]   ARTERIAL-WALLS GENERATE FROM PROSTAGLANDIN ENDOPEROXIDES A SUBSTANCE (PROSTAGLANDIN-X) WHICH RELAXES STRIPS OF MESENTERIC AND CELIAC ARTERIES AND INHIBITS PLATELET-AGGREGATION [J].
BUNTING, S ;
GRYGLEWSKI, R ;
MONCADA, S ;
VANE, JR .
PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1976, 12 (06) :897-913
[3]   3-(1-IMIDAZOLYLMETHYL) INDOLES - POTENT AND SELECTIVE INHIBITORS OF HUMAN-BLOOD PLATELET THROMBOXANE SYNTHETASE [J].
CROSS, PE ;
DICKINSON, RP ;
PARRY, MJ ;
RANDALL, MJ .
AGENTS AND ACTIONS, 1981, 11 (03) :274-280
[4]   PROSTACYCLIN (PGX) IS ENDOGENOUS METABOLITE RESPONSIBLE FOR RELAXATION OF CORONARY-ARTERIES INDUCED BY ARACHIDONIC-ACID [J].
DUSTING, GJ ;
MONCADA, S ;
VANE, JR .
PROSTAGLANDINS, 1977, 13 (01) :3-15
[5]   Nitration of phenyl substituents of heterocyclic nuclei. [J].
Forsyth, R ;
Pyman, FL .
JOURNAL OF THE CHEMICAL SOCIETY, 1930, :397-403
[6]   ARTERIAL-WALLS ARE PROTECTED AGAINST DEPOSITION OF PLATELET THROMBI BY A SUBSTANCE (PROSTAGLANDIN-X) WHICH THEY MAKE FROM PROSTAGLANDIN ENDOPEROXIDES [J].
GRYGLEWSKI, RJ ;
BUNTING, S ;
MONCADA, S ;
FLOWER, RJ ;
VANE, JR .
PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1976, 12 (05) :685-713
[7]   PROSTAGLANDIN ENDOPEROXIDES - NOVEL TRANSFORMATIONS OF ARACHIDONIC-ACID IN HUMAN PLATELETS [J].
HAMBERG, M ;
SAMUELSS.B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (09) :3400-3404
[8]   THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES [J].
HAMBERG, M ;
SVENSSON, J ;
SAMUELSSON, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :2994-2998
[9]  
HOPFINGER AJ, 1982, MOL PHARMACOL, V21, P187
[10]   HIGHLY SELECTIVE INHIBITORS OF THROMBOXANE SYNTHETASE .1. IMIDAZOLE DERIVATIVES [J].
IIZUKA, K ;
AKAHANE, K ;
MOMOSE, DI ;
NAKAZAWA, M ;
TANOUCHI, T ;
KAWAMURA, M ;
OHYAMA, I ;
KAJIWARA, I ;
IGUCHI, Y ;
OKADA, T ;
TANIGUCHI, K ;
MIYAMOTO, T ;
HAYASHI, M .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (10) :1139-1148