INFLUENCE OF NEBIVOLOL ON THE CARDIOVASCULAR HEMODYNAMICS DURING POSTURAL CHANGES AND ISOMETRIC-EXERCISE

被引：9

作者：

DUPREZ, D

LEFEBVRE, R

DEBACKER, T

DESUTTER, P

TROUERBACH, J

CLEMENT, DL

机构：

[1] Department of Cardiology and Angiology, University Hospital, Gent, 9000

[2] J. F. Heymans Institute for Pharmacology, University Hospital, Gent

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1991年 / 5卷 / 04期

关键词：

CARDIOVASCULAR HEMODYNAMICS; ISOMETRIC EXERCISE; NEBIVOLOL; POSTURAL CHANGES;

D O I：

10.1007/BF03029745

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nebivolol (R67555), a drug with beta-1 receptor antagonizing properties, was administered once daily (5 mg) for 7 days in 10 healthy volunteers. The hemodynamic parameters were measured noninvasively during postural changes (supine, sitting, standing) and during isometric handgrip at 50% maximal voluntary contraction, before and 3, 8, and 23 hours after the first nebivolol intake of 5 mg; the same measurements were done 23 hours after the last intake. Nebivolol lowered arterial blood pressure acutely and chronically due to a decrease in heart rate and cardiac output. The stroke volume seemed to be preserved, while the total peripheral vascular resistance did not change. Nebivolol did not change the orthostatic responses, except that the absolute value was lowered. Nebivolol was unable to prevent the blood pressure increase during isometric handgrip. However, this blood pressure increase was obtained by an increase in the total peripheral vascular resistance and not by an increase in the cardiac output, as observed during control measurements before nebivolol intake.

引用

页码：709 / 717

页数：9

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