HUMAN ENDOMETRIAL STROMAL CELLS AND DECIDUAL CELLS EXPRESS CLUSTER OF DIFFERENTIATION (CD)13 ANTIGEN AMINOPEPTIDASE-N AND CD10 ANTIGEN NEUTRAL ENDOPEPTIDASE

被引：81

作者：

IMAI, K ^{[1
]}

MAEDA, M ^{[1
]}

FUJIWARA, H ^{[1
]}

OKAMOTO, N ^{[1
]}

KARIYA, M ^{[1
]}

EMI, N ^{[1
]}

TAKAKURA, K ^{[1
]}

KANZAKI, H ^{[1
]}

MORI, T ^{[1
]}

机构：

[1] KYOTO UNIV,CHEST DIS RES INST,SAKYO KU,KYOTO 606,JAPAN

来源：

BIOLOGY OF REPRODUCTION | 1992年 / 46卷 / 03期

关键词：

D O I：

10.1095/biolreprod46.3.328

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

With specific monoclonal antibodies, we found that human endometrial stromal cells and decidual cells express two function-related surface antigens. Indirect immunofluorescence staining revealed that both endometrial stromal cells and decidual cells during the first trimester of pregnancy expressed cluster of differentiation (CD) 13 antigen and CD10 antigen, which are identical to aminopeptidase N and neutral endopeptidase, respectively. By flow cytometric analysis, CD13 antigen was detected on 82-93% of the examined cells, and CD10 antigen was detected on 75-93% of the examined cells in endometrial stromal cell-enriched preparations. Furthermore, peptidase activity was detected in these cell preparations by an assay based on the hydrolysis of alanine-p-nitroanilide into p-nitroaniline and alanine.

引用

页码：328 / 334

页数：7

共 31 条

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