SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF ANTIOXIDANTS, 4-ALKYLTHIO-ORTHO-ANISIDINE DERIVATIVES

被引：9

作者：

KOMESHIMA, N

OSAWA, T

NISHITOBA, T

JINNO, Y

KIRIU, T

机构：

[1] Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd, Takasaki, Gunma 370-12, 3, Miyahara-cho

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 02期

关键词：

4-ALKYLTHIO-ORTHO-ANISIDINE; 4-PROPYLTHIO-ORTHO-ANISIDINE; ANTIINFLAMMATORY; ANTIOXIDANT; ARTHUS REACTION;

D O I：

10.1248/cpb.40.351

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to search for anti-inflammatory agents against autoimmune diseases, we synthesized 4-alkylthio-omicron-anisidine derivatives possessing antioxidant activity, and tested them for anti-inflammatory activity against the Arthus reaction in mice. Experimental inflammations, including the Arthus reaction, concanavalin A, phorbol ester and pyrophosphate-induced edemas in rats were inhibited by 4-propylthio-omicron-anisidine, which inhibited autoxidation of rat brain homogenate and suppressed the lipopolysaccharide-induced increase in the plasma malondialdehyde level in mice. An antioxidant may be an effective agent in immune complex type inflammation where active oxygen species play an important role.

引用

页码：351 / 356

页数：6

共 18 条

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[2] AN UNUSUAL PROFILE OF ACTIVITY OF A NEW BASIC ANTI-INFLAMMATORY DRUG, TIMEGADINE [J].