STRUCTURAL CAUSES OF CARDIAC DYSFUNCTION IN UREMIA

被引：12

作者：

RAMBAUSEK, M

AMANN, K

MALL, G

RITZ, E

机构：

[1] Department of Internal Medicine, University of Heidelberg, Heidelberg

[2] Department of Pathology, University of Heidelberg, Heidelberg

来源：

RENAL FAILURE | 1993年 / 15卷 / 03期

关键词：

ANGINA PECTORIS; CARDIAC DISEASE; CARDIAC INTERSTITIAL FIBROSIS; LEFT VENTRICULAR HYPERTROPHY; UREMIA;

D O I：

10.3109/08860229309054955

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

While coronary heart disease is undoubtedly a major cause of cardiac morbidity and mortality in uremia, important noncoronary problems contribute to the common presence of cardiac problems. Based on clinical and experimental studies, we could show: (i) Left ventricular hypertrophy (LVH) can be dissociated, at least in part, from elevation of blood pressure. (ii) In uremia, PTH-dependent intermyocardiocytic fibrosis occurs; it may account, at least in part, for disturbed LV compliance and contribute to the arrhythmogenic potential. (iii) Blood pressure-independent abnormalities of intracardiac arterioles and reduced myocardial capillary supply are observed.

引用

页码：421 / 428

页数：8

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