DESIGN OF REGULATED ION CHANNELS USING MEASUREMENTS OF CIS-TRANS ISOMERIZATION IN SINGLE MOLECULES

被引:58
作者
WOOLLEY, GA
JAIKARAN, ASI
ZHANG, ZH
PENG, SY
机构
[1] Department of Chemistry, University of Toronto, Toronto, M5S 1A1
关键词
D O I
10.1021/ja00121a002
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A key component in the design of artificial ion channels is the design of regulatory elements. We have synthesized a derivative of the peptide ion channel, gramicidin, in which an amino group is connected to the mouth of the channel by a Linker containing a carbamate group. Thermal cis-trans isomerization of the carbamate, which can be detected at the single-molecule level, is found to regulate the flux of Cs+ ions through the channel. The predictability of the system suggests that design of more sophisticated types of channel regulation will be possible.
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页码:4448 / 4454
页数:7
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