EXTRAPOLATION OF PHYSIOLOGICAL-PARAMETERS FOR PHYSIOLOGICALLY-BASED SIMULATION-MODELS

被引：19

作者：

FISEROVABERGEROVA, V

机构：

[1] Department of Anesthesiology, University of Miami School of Medicine, Miami, FL 33101

来源：

TOXICOLOGY LETTERS | 1995年 / 79卷 / 1-3期

关键词：

INHALED DOSE; PHARMACOKINETIC COMPARTMENTS; PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS; RISK ASSESSMENT;

D O I：

10.1016/0378-4274(95)03359-S

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Masses of organs and fluids, pulmonary ventilation and cardiac output and its distribution are the basic input data used in physiologically based pharmacokinetic models. Since these parameters are rarely measured in pharmacokinetic studies, the values found in reference books or extrapolated to meet the specific exposure conditions are used in the models. In this review of the extrapolation of pertinent physiological parameters, power equations for scaling across mammals, adjustments to body build (lean body mass) and physical activity of humans and their significance for risk assessment of human exposure to solvents using animal data are assessed.

引用

页码：77 / 86

页数：10

共 39 条

[1] QUANTITATIVE RELATIONS IN THE PHYSIOLOGICAL CONSTITUTIONS OF MAMMALS [J].