AMBRA1-induced mitophagy: A new mechanism to cope with cancer?

被引：24

作者：

Strappazzon, Flavie ^{[1
,2
]}

Cecconi, Francesco ^{[1
,2
,3
]}

机构：

[1] IRCCS Fondazione Santa Lucia, Rome, Italy

[2] Univ Roma Tor Vergata, Dept Biol, Rome, Italy

[3] Danish Canc Soc Res Ctr, Unit Cell Stress & Survival, Copenhagen, Denmark

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 02期

关键词：

AMBRA1; mitophagy; cancer;

D O I：

10.4161/23723556.2014.975647

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Dysfunctions in mitophagy, the process by which mitochondria are eliminated, are associated with cancer. We found that the proautophagic protein AMBRA1 (activating molecule in beclin 1 regulated autophagy) binds the autophagosome adapter LC3, and that this interaction is crucial for mitochondrial clearance with or without involvement of the E3-ligase PARKIN. The discovery of a novel mitophagy pathway has the potential to promote new anticancer strategies.

引用

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