NEUROHUMORAL PATHWAYS MEDIATING STRESS-INDUCED INHIBITION OF GASTRIC-ACID SECRETION IN RATS

被引：25

作者：

LENZ, HJ ^{[1
]}

DRUGE, G ^{[1
]}

机构：

[1] UNIV HAMBURG,DEPT MED,NEUROGASTROENTEROL LAB,W-2000 HAMBURG 13,GERMANY

来源：

GASTROENTEROLOGY | 1990年 / 98卷 / 06期

关键词：

D O I：

10.1016/0016-5085(90)91080-P

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In awake rats, physical restraint inhibited pentagastrin-stimulated gastric acid secretion by more than 50%. This inhibitory effect was abolished by either ganglionic or noradrenergic blockade. Adrenalectomy, as well as pretreatment with a vasopressin V1-receptor antagonist, significantly attenuated the gastric inhibitory effect in response to stress. In contrast, neither truncal vagotomy nor hypophysectomy or opiate blockade prevented stress-induced inhibition of gastric acid secretion. These findings indicate that stress-induced inhibition of gastric acid secretion in rats is mediated by autonomic, noradrenergic efferents as well as by adrenal and vasopressindependent pathways. Vagal efferents, opiate pathways, and the pituitary gland do not seem to be involved. © 1990.

引用

页码：1490 / 1492

页数：3

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