SUPEROXIDE-DISMUTASE AND CATALASE AS THERAPEUTIC AGENTS FOR HUMAN-DISEASES - A CRITICAL-REVIEW

被引：173

作者：

GREENWALD, RA

机构：

[1] Division of Rheumatology, Long Island Jewish Medical Center, New Hyde Park

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 8卷 / 02期

关键词：

Animal models; Bronchopulmonary dysplasia; Catalase; Free radicals; Ischemia/reperfusion; Superoxide Dismutase;

D O I：

10.1016/0891-5849(90)90092-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The list of human and animal diseases for which oxygen radical scavenging therapy is being recommended continues to grow, based primarily on inferential evidence suggesting a potential role for oxygen-derived free radicals in various types of pathophysiology. Some distinct advances in pharmacologic manipulation of protein scavengers have been made which could ultimately greatly enhance the use of these reagents as drugs, as well as some innovative techniques for drug delivery (direct injection via endoscopy, iontophoresis). Unfortunately, most of the therapeutic reports in the literature, almost all of which are based on usage of standard (native) SOD and/ or catalase, are still anecdotal and/or uncontrolled. A review of the human disease/treatment literature suggests that further tightening of the scientific design of such trials is still badly needed; hopefully better experimental design will be applied when products such as PEG conjugates or genetically engineered polymers are ready for testing. © 1990.

引用

页码：201 / 209

页数：9

共 64 条

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