ANTICHOLINERGIC ACTION OF PEONY ROOT AND ITS ACTIVE CONSTITUENTS

被引：26

作者：

KOBAYASHI, M ^{[1
]}

UEDA, C ^{[1
]}

AOKI, S ^{[1
]}

TAJIMA, K ^{[1
]}

TANAKA, N ^{[1
]}

YAMAHARA, J ^{[1
]}

机构：

[1] KYOTO PHARMACEUT UNIV, YAMASHINA KU, KYOTO 607, JAPAN

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1990年 / 110卷 / 12期

关键词：

PEONY ROOT; PAEONIFLORIN; ANTICHOLINERGIC ACTION; PROXIMAL COLON; HERBAL MEDICINE;

D O I：

10.1248/yakushi1947.110.12_964

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Anticholinergic action of Paeony root was examined in in vivo experiments with rat in order to substantiate the presence of analgesic, antispasmic and antidiarrheal properties. The 50% methanol extract of Paeony root was found to be effective. Fractionation of 50% methanol extract through column chromatography revealed that paeoniflorin was one of the active constituents in anticholinergic action in vivo, but in vitro, paeoniflorin had no effect on contractile responses of isolated rat proximal colon to the carbachol and KCl.

引用

页码：964 / 968

页数：5