THE ENVELOPE GLYCOPROTEIN OF EBOLA VIRUS CONTAINS AN IMMUNOSUPPRESSIVE-LIKE DOMAIN SIMILAR TO ONCOGENIC RETROVIRUSES

被引：108

作者：

VOLCHKOV, VE

BLINOV, VM

NETESOV, SV

机构：

[1] Institute of Molecular Biology, Koltsova

来源：

FEBS LETTERS | 1992年 / 305卷 / 03期

关键词：

EBOLA VIRUS; IMMUNOSUPPRESSIVE DOMAIN; CDNA; AMINO ACID SEQUENCE;

D O I：

10.1016/0014-5793(92)80662-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic RNA of a Zaire strain of Ebola virus was cloned. and cDNA inserts specific for the glycoprotein gene were isolated and sequenced. The determined sequence has only one open reading frame encoding 318 amino acids and is part of ORF-4 on the plus RNA strand. The putative transcriptional stop site (3' AAUUCUUUUU 5') and the transcriptional start site (3' AACUACUUCUAAUU.. 5') were identified. Computer-assisted comparison of the amino acid sequence of the C-terminal part of protein encoded by ORF-4 of Ebola virus with sequences of the proteins present in the SWISSPROT and EMBL banks revealed significant homology with the 'immunosuppressive domain' of the p15E envelope proteins of various oncogenic retroviruses. Thc possible role of such a homology is discussed.

引用

页码：181 / 184

页数：4

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