POSTMORTEM PROTON MAGNETIC-RESONANCE SPECTROMETRIC MEASURES OF BRAIN-REGIONS IN PATIENTS WITH A PATHOLOGICAL DIAGNOSIS OF ALZHEIMERS-DISEASE AND MULTIINFARCT DEMENTIA

被引：18

作者：

BESSON, JAO

BEST, PV

SKINNER, ER

机构：

[1] UNIV ABERDEEN,DEPT PATHOL,ABERDEEN AB9 2ZD,SCOTLAND

[2] UNIV ABERDEEN,DEPT BIOCHEM,ABERDEEN AB9 2ZD,SCOTLAND

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1992年 / 160卷

关键词：

D O I：

10.1192/bjp.160.2.187

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In-vitro spectrometric measures were made of spin-lattice (T1) and spin-spin (T2) relaxation times of samples of grey and white matter from the brains of 15 patients with a pathological diagnosis of Alzheimer's disease, 5 with multi-infarct dementia, and 11 non-demented subjects. Relaxation times were significantly greater in the parietal white matter and temporal white matter of patients with Alzheimer's disease compared with that of the other subjects. This was associated with an increase in tissue water content. These findings confirm measures obtained in some imaging studies.

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页码：187 / 190

页数：4

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