A DEMENTING ILLNESS ASSOCIATED WITH A NOVEL INSERTION IN THE PRION PROTEIN GENE

被引：91

作者：

OWEN, F

POULTER, M

COLLINGE, J

LEACH, M

LOFTHOUSE, R

CROW, TJ

HARDING, AE

机构：

[1] CLIN RES CTR,DIV PSYCHIAT,HARROW HA1 3UJ,MIDDX,ENGLAND

[2] ST MARYS HOSP,LONDON,ENGLAND

[3] NATL HOSP,LONDON WC1N 3BG,ENGLAND

来源：

MOLECULAR BRAIN RESEARCH | 1992年 / 13卷 / 1-2期

关键词：

PRION PROTEIN; CREUTZFELDT-JAKOB DISEASE; TRANSMISSIBLE DEMENTIA; SPONGIFORM ENCEPHALOPATHY;

D O I：

10.1016/0169-328X(92)90056-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Following our previous report of an 144-bp insertion in the open reading frame of the prion protein (PrP) gene, we have now identified a larger, 216-bp, insertion in the gene. The insertion which is in frame encodes 9 extra octapeptide repeat sequences in addition to the 5 repeats normally present and represents the largest insertion so far detected in the PrP gene.

引用

页码：155 / 157

页数：3

共 13 条

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