PREPARATION AND CHARACTERIZATION OF BUPIVACAINE-LOADED POLYLACTIDE AND POLYLACTIDE-CO-GLYCOLIDE MICROSPHERES

被引：59

作者：

LECORRE, P

LEGUEVELLO, P

GAJAN, V

CHEVANNE, F

LEVERGE, R

机构：

[1] Laboratoire de Pharmacie Galénique et Biopharmacie, Faculté de Pharmacie, Université de Rennes I, 35043 Rennes

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 107卷 / 01期

关键词：

BUPIVACAINE; POLYLACTIDE; POLYLACTIDE-CO-GLYCOLIDE; MICROSPHERE; CONTROLLED RELEASE; INTRATHECAL ADMINISTRATION; INTRAPERITONEAL ADMINISTRATION;

D O I：

10.1016/0378-5173(94)90300-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Various bupivacaine-loaded microsphere systems have been prepared from polyractide-co-glycolide (PLGA) and from blends of different molecular weight polylactide (PLA) by a solvent evaporation-extraction method. In vitro drug release profiles displayed significant differences between polymers. Among PLA microspheres, the initial release was accelerated with increasing proportion of low molecular weight PLA. Preliminary pharmacokinetic studies following intrathecal and intraperitoneal administration of different bupivacaine-loaded microspheres in rabbits illustrated the controlled release of this drug.

引用

页码：41 / 49

页数：9

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