NEONATAL NEUTROPENIA IN LOW-BIRTH-WEIGHT PREMATURE-INFANTS

被引:31
作者
GESSLER, P
LUDERS, R
KONIG, S
HAAS, N
LASCH, P
KACHEL, W
机构
[1] Department of Pediatrics, University Hospital of Mannheim, Mannheim
关键词
NEONATAL NEUTROPENIA; LOW BIRTH-WEIGHT PREMATURE INFANTS; INCIDENCE; CAUSES; OUTCOME;
D O I
10.1055/s-2007-994396
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Neutropenia, as defined by common reference values, occurs often in neonates. Its incidence, causes, and clinical consequences have not been studied extensively in premature neonates. Of 208 consecutive infants with birthweight up to 2000 g, 121 (58%) had neutropenia. Low gestational age and low birthweight correlated with the incidence of neutropenia. Less than half of the neutropenic episodes could be attributed to infections, the others were related to specific perinatal events and due to drug therapy or were of unknown cause. Neutropenia following treatment with certain antibiotics was the most common cause of neutropenia occurring after the second week of life. The high incidence of neutropenia in premature neonates raises questions about application of these reference ranges to low birthweight infants and suggests the need for new reference values.
引用
收藏
页码:34 / 38
页数:5
相关论文
共 32 条
  • [1] Benuck I., David R.J., Sensitivity of published neutrophil indexes in identifying newborn infants with sepsis, J Pediatr, 103, pp. 961-963, (1983)
  • [2] Gerdes J.S., Clinitopathologic approach to the diagnosis of neonatal sepsis, Clin Perinatol, 18, pp. 361-381, (1991)
  • [3] Philip A.G.S., Hewitt J.R., Early diagnosis of neonatal sepsis, Pediatrics, 65, pp. 1036-1041, (1980)
  • [4] Manroe B.L., Weinberg A.G., Rosenfeld C.R., Browne R., The neonatal blood count in health and disease. I. Reference values for neutrophilic cells, J Pediatr, 95, pp. 89-98, (1979)
  • [5] Coulombel L., Dehan M., Tchernia G., Et al., The number of polymorphonuclear leukocytes in relation to gestational age in the newborn, Acta Paediatr Scand, 68, pp. 709-711, (1979)
  • [6] Davies N.P., Buggins A.G.S., Snijders R.J.M., Et al., Blood leukocyte count in the human fetus, Arch Dis Child, 67, pp. 399-403, (1992)
  • [7] Weinberg A.G., Rosenfield C.R., Manroe B.L., Browne R., Neonatal blood cell count in health and disease. I. I. Values for lymphocytes, monocytes, and eosinophils, J Pediatr, 106, pp. 462-466, (1985)
  • [8] Xanthou M., Leucocyte blood picture in healthy full-term and premature babies during neonatal period, Arch Dis Child, 45, pp. 242-249, (1970)
  • [9] Lloyd B.W., Oto A., Normal values Tor mature and immature neutrophils in very preterm babies, Arch Dis Child, 53, pp. 233-235, (1982)
  • [10] Baley J.E., Stork E.K., Warkentin P.I., Shurin S.B., Neonatal neutropenia: clinical manifestations, cause, and outcome, Am J Dis Child, 142, pp. 1161-1165, (1988)