MONOSOMY 1P IS CORRELATED WITH ENHANCED IN-VIVO GLUCOSE-METABOLISM IN MENINGIOMAS

被引：34

作者：

HENN, W

CREMERIUS, U

HEIDE, G

LIPPITZ, B

SCHRODER, JM

GILSBACH, JM

BULL, U

ZANG, KD

机构：

[1] RHEIN WESTFAL TH AACHEN,DEPT NUCL MED,W-5100 AACHEN,GERMANY

[2] RHEIN WESTFAL TH AACHEN,DEPT NEUROPATHOL,AACHEN,GERMANY

[3] RHEIN WESTFAL TH AACHEN,DEPT NEUROSURG,W-5100 AACHEN,GERMANY

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 79卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)00135-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake of 25 human meningiomas was preoperatively evaluated in vivo by positron-emission tomography (PET). After surgery, meningioma biopsies were analyzed cytogenetically. Five meningiomas showed partial monosomy for chromosome 1p additional to other typical chromosome aberrations. This aberrant karyotype was correlated with increased FDG uptake. Three of five meningiomas with monosomy 1p were classified as grade II according to WHO, while only one of 20 tumors without monosomy 1p was classified as grade II. Thus, monosomy 1p and elevated FDG uptake in PET ore to be regarded as cytogenetic and metabolic parameters for the aggressiveness of meningiomas.

引用

页码：144 / 148

页数：5

共 21 条

[1]

ALAVI JB, 1988, CANCER, V62, P1074, DOI 10.1002/1097-0142(19880915)62:6<1074::AID-CNCR2820620609>3.0.CO

[2]

2-H

[3] CYTOGENETICS OF HUMAN-MALIGNANT MELANOMA AND PREMALIGNANT LESIONS [J].