Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats

被引:8
作者
Bharti, Vijay K. [1 ,2 ]
Srivastava, R. S. [1 ]
Subramaian, P. [3 ]
Spence, D. Warren
Pandi-Perumal, S. R. [4 ]
Brown, Gregory M. [5 ,6 ]
机构
[1] IVRI, Div Physiol & Climatol, Neurophysiol Lab, Izatnagar 243122, Uttar Pradesh, India
[2] Minist Def, DIHAR, Nutr & Toxicol Lab, DRDO, Leh 194101, India
[3] Annamalai Univ, Fac Sci, Dept Biochem & Biotechnol, Annamalainagar 608002, India
[4] Somnogen Inc, Toronto, ON M6H 1C5, Canada
[5] Univ Toronto, Dept Psychiat, Oakville, ON L6L 6L5, Canada
[6] Ctr Addict & Mental Hlth, Toronto, ON M5T 1R8, Canada
关键词
D O I
10.4061/2011/142896
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
The cerebral epiphysis (pineal gland) secrets melatonin and number of other proteins and peptides. It was thus hypothesized that antioxidant properties of epiphyseal proteins and melatonin could potentially benefit from exogenous therapies. In view of the therapeutic potential of these proteins, the present experiment was conducted to investigate the effect of buffalo epiphyseal proteins (BEP, at 100 mu g/kg BW, i.p.) and melatonin (MEL, at 10 mg/kg BW, i.p) on changes in hepatic and renal antioxidant enzymes of adult female Wistar rats. Buffalo epiphyseal proteins significantly (P < .05) increased hepatic lipid peroxidation (LPO), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), reduced glutathione (GSH), and renal LPO, catalase (CAT), GR, GSH, GPx levels as compared to control animals. Similarly, MEL treatment significantly (P < .05) up-regulated hepatic SOD and GPx activity, whereas CAT, GR, GPx, and GSH levels in renal tissues were increased while SOD and LPO remained unaffected. Buffalo epiphyseal protein treatment produced greater effects on hepatic GPx and renal CAT and GSH levels than did MEL. These findings support the conclusion that buffalo epiphyseal proteins and melatonin activate a number of antioxidant mechanisms in hepatic and renal tissues.
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页数:5
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