Multifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineering

被引：108

作者：

Green, Jordan D. ^{[1
,2
]}

Tollemar, Viktor ^{[1
,2
]}

Dougherty, Mark ^{[1
,2
]}

Yan, Zhengjian ^{[2
,3
]}

Yin, Liangjun ^{[2
,3
]}

Ye, Jixing ^{[2
,4
]}

Collier, Zachary ^{[1
,2
]}

Mohammed, Maryam K. ^{[1
,2
]}

Haydon, Rex C.

Luu, Hue H. ^{[2
]}

Kang, Richard ^{[2
]}

Lee, Michael J. ^{[2
]}

Ho, Sherwin H. ^{[2
]}

He, Tong-Chuan ^{[2
]}

Shi, Lewis L. ^{[2
]}

Athiviraham, Aravind ^{[2
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[2] Univ Chicago, Med Ctr, Dept Orthopaed Surg & Rehabil Med, 5841 South Maryland Ave,MC 3079, Chicago, IL 60637 USA

[3] Chongqing Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Chongqing 400016, Peoples R China

[4] Chongqing Univ, Sch Bioengn, Chongqing, Peoples R China

来源：

GENES & DISEASES | 2015年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

BMPs; Cartilage; Cell signaling; Chondrogenesis; FGF; Regenerative medicine; Sox9; TGFb;

D O I：

10.1016/j.gendis.2015.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature. Current surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous tissue. Here, we review the current understanding of the most important biological regulators of chondrogenesis and their interactions, to provide insight into potential applications for cartilage tissue engineering. These include various signaling pathways, including fibroblast growth factors (FGFs), transforming growth factor b (TGF-b)/bone morphogenic proteins (BMPs), Wnt/b-catenin, Hedgehog, Notch, hypoxia, and angiogenic signaling pathways. Transcriptional and epigenetic regulation of chondrogenesis will also be discussed. Advances in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering. Copyright (C) 2015, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

引用

页码：307 / 327

页数：21

共 340 条

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