DEPRESSION OF THE CA2+-ATPASE ACTIVITY OF THE RAT-LIVER ENDOPLASMIC-RETICULUM BY THE LIVER-TUMOR PROMOTERS 1,1,1-TRICHLORO-2,2-BIS(P-CHLOROPHENYL)-ETHANE AND PHENOBARBITAL

被引：7

作者：

ADENUGA, GA

BABABUNMI, EA

HENDRICKSE, RG

机构：

[1] UNIV IBADAN,DEPT BIOCHEM,BIOMEMBRANE RES & BIOTECHNOL LABS,IBADAN,NIGERIA

[2] UNIV LIVERPOOL,LIVERPOOL SCH TROP MED,DEPT TROP PAEDIAT & INT CHILD HLTH,LIVERPOOL L3 5QA,ENGLAND

来源：

TOXICOLOGY | 1992年 / 71卷 / 1-2期

关键词：

ENDOPLASMIC RETICULUM; CA2+-ATPASE; LIVER TUMOR PROMOTERS;

D O I：

10.1016/0300-483X(92)90049-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of a short-term in vivo administration of two liver tumour promoters (phenobarbital and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane on rat liver endoplasmic reticulum Ca2+-ATPase were investigated. The specific activity values of this membrane-bound enzyme significantly decreased (P < 0.01) by 51% for phenobarbital-treated rats and by 48% for 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane-treated rats compared with control animals. The depression of liver endoplasmic reticulum Ca2+-ATPase appears to be a manifestation of the toxicological effect of tumour promoters.

引用

页码：1 / 6

页数：6

共 33 条

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