HYPOTHALAMIC HISTAMINE MODULATES ADAPTIVE-BEHAVIOR OF RATS AT HIGH ENVIRONMENTAL-TEMPERATURE

被引：41

作者：

FUJIMOTO, K ^{[1
]}

SAKATA, T ^{[1
]}

OOKUMA, K ^{[1
]}

KUROKAWA, M ^{[1
]}

YAMATODANI, A ^{[1
]}

WADA, H ^{[1
]}

机构：

[1] OSAKA UNIV, FAC MED, DEPT PHARMACOL 2, OSAKA 530, JAPAN

来源：

EXPERIENTIA | 1990年 / 46卷 / 03期

关键词：

adaptive behavior; environmental temperature; Histamine; hypothalamus;

D O I：

10.1007/BF01951767

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Histamine content in the rat hypothalamus was lower at 4°C and higher at 31°C compared to that at 21°C. Pretreatment with α-fluoromethylhistidine, a 'suicide' inhibitor of histidine decarboxylase, attenuated both the increased level of hypothalamic histamine and rat adaptive behavior at 31°C. Increase of histamine content in the hypothalamus appears to be an important factor contributing to rat adaptive behavior to high environmental temperature. © 1990 Birkhäuser Verlag.

引用

页码：283 / 285

页数：3

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