INDUCTION OF PEROXISOMAL BETA-OXIDATION GENES BY RETINOIC ACID IN CULTURED RAT HEPATOCYTES

被引：44

作者：

HERTZ, R ^{[1
]}

BARTANA, J ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT BIOCHEM,POB 1172,IL-91010 JERUSALEM,ISRAEL

来源：

BIOCHEMICAL JOURNAL | 1992年 / 281卷

关键词：

D O I：

10.1042/bj2810041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retinoic acid is reported here to induce peroxisomal beta-oxidation activities in cultured rat hepatocytes, with a concomitant increase in respective peroxisomal mRNAs. The concentrations of retinoic acid required for inducing liver peroxisomal acyl-CoA oxidase were similar to those required for inducing liver transglutaminase. A putative 5'-flanking response element for retinoic acid may be found within the enhancer region involved in the induction of peroxisomal genes by xenobiotic amphipathic carboxylates.

引用

页码：41 / 43

页数：3

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