INTERACTION OF CARDIAC ALPHA-ACTININ AND ACTIN IN THE PRESENCE OF DOXORUBICIN

被引：11

作者：

DALLEDONNE, I ^{[1
]}

MILZANI, A ^{[1
]}

CONTINI, P ^{[1
]}

BERNARDINI, G ^{[1
]}

COLOMBO, R ^{[1
]}

机构：

[1] UNIV MILAN,DEPT BIOL,CELL BIOL LAB,VIA CELORIA 26,I-20133 MILAN,ITALY

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1992年 / 56卷 / 03期

关键词：

D O I：

10.1016/0014-4800(92)90039-E

中图分类号：

R36 [病理学];

学科分类号：

100104 [病理学与病理生理学];

摘要：

The therapeutic use of doxorubicin (an antitumoral antibiotic belonging to the anthracycline group) is limited by its cardiotoxicity. Adriamycin (DXR) causes myocardial subcellular damage, such as myocytolysis, disarray of actin filaments, and alterations in the Z-band with loss of sarcomeric organization. We studied the effect of stoichiometrical concentrations of DXR on the interaction between cardiac actin and α-actinin in solution. Doxorubicin inhibits the formation of α-actinin/actin tridimensional networks and bundles. The main effect of the drug seems to be on the size of the actin polymers. © 1992.

引用

页码：229 / 238

页数：10

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